Cobalamin deficiency and infertility

Cobalamin deficiency, hyperhomocysteinemia, and dementia

INTRODUCTION Although consensus guidelines recommend checking serum B12 in patients with dementia, clinicians are often faced with various questions: (1) Which patients should be tested? (2) What test should be ordered? (3) How are inferences made from such testing? (4) In addition to serum B12, should other tests be ordered? (5) Is B12 deficiency compatible with dementia of the Alzheimer's typ...

Diagnosis of cobalamin deficiency.

Helicobacter pylori and cobalamin deficiency.

We have read with interest Maktouf et al.’s letter about the etiological role of deficiencies of cobalamin or folate in megaloblastic anemia. In this large prospective series, they investigated 478 patients with megaloblastic changes in bone marrow smears and reported the demographic, biological and clinical findings in cobalamin-deficient patients and patients with pernicious anemia. Out of 43...

Effective treatment of cobalamin deficiency with oral cobalamin.

Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days. Therapeutic effectiveness was evaluated by measuring hemat...

Clinical spectrum and diagnosis of cobalamin deficiency.

To better estimate how frequently patients with low serum cobalamin (Cbl) levels in current clinical practice are truly deficient in Cbl and to determine the incidence of atypical or nonclassic presentations of Cbl deficiency, we prospectively studied 300 unselected consecutive patients with serum Cbl concentrations less than 200 pg/mL seen at two medical centers over a 2-year period. Baseline ...